Jan Baumbach studied computer science at Bielefeld University in Germany. His research career started at Rothamsted Research in Harpenden (UK) where he worked on computational methods for the integration of molecular biology data. He returned to the Center for Biotechnology in Bielefeld for his PhD studies  where he developed CoryneRegNet. Afterwards, at the University of California at Berkeley, he worked in the Algorithms group of Richard Karp on Transitivity Clustering, a novel clustering framework for large-scale biomedical data sets. From March 2010, Jan was head of the Computational Systems Biology group at the Max Planck Institute for Informatics in Saarbrücken, Germany. In October 2012, he moved to the University of Southern Denmark as head of the Computational BioMedicine group. His research concentrated on systems and network biomedicine. He was study program coordinator of the Computational BioMedicine program from 2015 to 2017. In January 2018 he moved to the Technical University of Munich as chair of the Experimental Bioinformatics (ExBio), where he developed computational methods for systems medicine and novel federated AI approaches ensuring privacy by design. In January 2021, the lab relocated to the University of Hamburg where Jan Baumbach became director of the Institute for Computational Systems Biology (CoSy.Bio). In 2023, he was appointed a Humboldt Scout through the Henriette Herz-Scouting-Program.