Network Exploration and Drug Repurposing on your website

Drugst.One is an easy-to-use online tool that helps researchers find new uses for existing drugs. It turns complex scientific software into a simple web interface, making it easier to explore how drugs, diseases, and proteins interact. This tool is especially helpful for scientists in drug research, as it offers a straightforward way to analyze and visualize data.

Cancer Driver Drug Interaction Explorer

CADDIE is a web application for drug repurposing in cancer integrating six human gene-gene and four drug-gene interaction databases, information regarding cancer driver genes, cancer-type specific mutation frequencies, gene expression information, genetically related diseases, and anticancer drugs. The website offers access to various network algorithms for identifying drug targets and drug repurposing candidates. It guides users from the selection of seed genes to the identification of therapeutic targets or drug candidates, making network medicine algorithms accessible for clinical research.

NeDRex 

NeDRex is an interactive network medicine platform for disease module identification and drug repurposing. It is build of three main components: a knowledgebase (NeDRexDB), a Cytoscape app (NeDRexApp), and an API (NeDRexAPI).

NeDRex integrates different data sources covering genes, drugs, drug targets, disease annotations, and their relationships. It allows for constructing heterogeneous biological networks, mining them for disease modules, prioritizing drugs targeting disease mechanisms, and statistical validation. The utility of NeDRex is shown with five specific use-cases in the paper (download from Nature).

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NeDRex-Web is a user interface for the large heterogeneous network database and drug repurposing platform NeDRex. It allows access to all features and data of other NeDRex interfaces, just without the need for downloading any software